I'm also worried about Jon Lester. He's a great story (cancer survivor, World Series clinching start, etc.). He's been terrific this year, if not the best pitcher on the staff, then second best to Matsuzaka, but I'm worried he won't last through the season.
He's 24 and he's pitched 146 innings this year; his previous career high was just 63. It's a tight race and if the Sox do go to the playoffs, he'll be asked to pitch into October and go well over 200 innings. In his case, because he's a it older, I'm less worried about the total number and more worried about the increase. I hope he doesn't run out of gas.